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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Help!! Positive for MTHFR C677t & A1298c and ANA
Hi Everyone,
If anyone wants to share any personal experience PLEASE feel free!!!
I’m new to the board and need help/advice!!!! I just tested positive for one copy of the C677t mutation and one copy of the A1298c mutation (MTHFR). And positive for ANA (1:160)
Can ANYONE PLEASE shed some light on any of this??? Does anyone have any of these mutations???? How is your Dr treating this? And are any of you pregnant with these mutations??
Any advise/input will be greatly appreciated!!!!
Thank you Everyone.
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Posted 10/22/11 11:18 PM  |
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MrsC529
LIF Infant
Member since 7/11 202 total posts
Name:
Danielle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Im on folgard (twice a day for the rest of my life) plus prenatal vitamins while tic
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| Posted 10/22/11 11:39 PM |
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PennyCat
Just call me mommy :)
Member since 7/08 19084 total posts
Name:
Jib
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
These are very common issues and women on this board get pregnant all the time with these issues, plus way more. I have two copies of MTHFR, ANA, and mannnnnnnny more immune/clotting and genetic issues  I'm taking Metanx, Lovenox (twice a day after transfer and throughout pregnancy), and baby aspirin. (although the protocol will be different for everyone.. like I said, I'm dealing with a complicated combo)
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| Posted 10/22/11 11:40 PM |
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classc1
LIF Adolescent
Member since 6/10 805 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
I have the same MTHFR mutation...it is called being compound heterozygous. We have one copy of each mutation. It is thought to be the second most serious of the MTHFR mutations with having two C mutations being the most serious. It is commonly treated with baby aspirin, Folgard or Metnax which contains 2.2 grams of folic acid and additional vitamins B6 and B 12. You may also want to switch to a pre-natal such as Neevo which helps to process folic acid better as this is the issue with having MTHFR. I am actually taking Lovenox and intralipids too this cycle after to help with both the MTHFR and immune issues. Because you also have Ana issues..you will likely be put on both Lovenox and intralipids or IVIG.
I would suggest that you join both the MTHFR and Reproductive Immunology groups at yahoo. A wealth of inforantion can be found there.
Message edited 10/23/2011 11:28:29 AM.
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| Posted 10/23/11 11:26 AM |
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DRMom
Two in Blue
Member since 5/05 20223 total posts
Name:
Melissa
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
I have 2 copies of MTHFR c677T which I have read is similar to you having the two different ones. This can make your blood a little more sticky and prone to clotting. I also had high ANA-mine was 1:320. I took:
Lovenox
Vitamin E
Baby Asprin
Prednisone-for the 1st 16 weeks of pregnancy
Progesterone which can be an immune moderator
I had healthy twin boys through IVF who are almost 3
Message edited 10/23/2011 11:54:58 AM.
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| Posted 10/23/11 11:54 AM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Thank you everyone for your help/insight. My head is still spinning...  with all info...
All of this boggles my mind since i was able to have an excellent pregnancy and a healthy baby boy (now a 2 1/2 year old)...
Now I'm just waiting on my/husbands genetic screening results. And going to a Rheumatologist to get blood work done....
Thank you ladies... 
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| Posted 10/23/11 3:25 PM |
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FLS2011
LIF Infant
Member since 8/11 282 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
I had an uncomplicated pregnancy and a healthy baby with no treatment at all and I'm homozygous for the C mutation. Have you had your homocysteine levels checked? They should also be checked when you get pregnant.
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| Posted 10/25/11 6:50 PM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by FLS2011
I had an uncomplicated pregnancy and a healthy baby with no treatment at all and I'm homozygous for the C mutation. Have you had your homocysteine levels checked? They should also be checked when you get pregnant.
I actually have not. I'll have to ask my Dr. about it... thanks!
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| Posted 10/25/11 10:32 PM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
OK- another question. Lovenox- I noticed a lot you ladies are on it... That is a blood thinner injection, correct? My Dr. prescribed me to take baby aspirin. Do you think i should bring that up with my Dr??? thank you !!!!!
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| Posted 10/25/11 10:51 PM |
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gina409
TWINS!
Member since 12/09 27635 total posts
Name:
g
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
i have the 2 C mutations and have been on metnax,baby asprinand lovenox for them
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| Posted 10/25/11 10:52 PM |
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FLS2011
LIF Infant
Member since 8/11 282 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by Tylersmom
OK- another question. Lovenox- I noticed a lot you ladies are on it... That is a blood thinner injection, correct? My Dr. prescribed me to take baby aspirin. Do you think i should bring that up with my Dr??? thank you !!!!!
I'm not currently on Lovenox but would be if I got pregnant, along with progesterone. I'm currently on baby aspirin and Folgard (a prescription vitamin that has lots of extra folic acid and helps b/c the MTHFR affects how you process folate). I would definitely bring up any meds that you are on to your Dr.
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| Posted 10/26/11 8:17 AM |
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Leb
LIF Adult
Member since 12/09 4166 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
I have a copy of A and C too.
I was told baby aspirin and metnax for life. Also I was told somethign where metnax has "active ingredients", and other vitamins like folgard has "inactive" which doesn't work as well.
I was told lovenox was "too agressive" for me and have been doing intralipids.
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| Posted 10/26/11 9:39 AM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by FLS2011
Posted by Tylersmom
OK- another question. Lovenox- I noticed a lot you ladies are on it... That is a blood thinner injection, correct? My Dr. prescribed me to take baby aspirin. Do you think i should bring that up with my Dr??? thank you !!!!!
I'm not currently on Lovenox but would be if I got pregnant, along with progesterone. I'm currently on baby aspirin and Folgard (a prescription vitamin that has lots of extra folic acid and helps b/c the MTHFR affects how you process folate). I would definitely bring up any meds that you are on to your Dr.
I'm currently on baby aspirin, Progesterone ,Folgard and prenatals. My Dr. also wants me to go on Clomid (a little hesitant about taking it  )
I'll see how this pains out...
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| Posted 10/26/11 9:06 PM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by Leb
I have a copy of A and C too.
I was told baby aspirin and metnax for life. Also I was told somethign where metnax has "active ingredients", and other vitamins like folgard has "inactive" which doesn't work as well.
I was told lovenox was "too agressive" for me and have been doing intralipids.
SO- is baby aspirin not strong enough for a blood thinner that you and others had to go on intralipids or Lovenox ???
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| Posted 10/26/11 9:16 PM |
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FLS2011
LIF Infant
Member since 8/11 282 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by Tylersmom
Posted by FLS2011
Posted by Tylersmom
OK- another question. Lovenox- I noticed a lot you ladies are on it... That is a blood thinner injection, correct? My Dr. prescribed me to take baby aspirin. Do you think i should bring that up with my Dr??? thank you !!!!!
I'm not currently on Lovenox but would be if I got pregnant, along with progesterone. I'm currently on baby aspirin and Folgard (a prescription vitamin that has lots of extra folic acid and helps b/c the MTHFR affects how you process folate). I would definitely bring up any meds that you are on to your Dr.
I'm currently on baby aspirin, Progesterone ,Folgard and prenatals. My Dr. also wants me to go on Clomid (a little hesitant about taking it )
I'll see how this pains out...
I forgot to mention I take a prenatal too. Clomid for clotting issues or something else? I've never heard of it for clotting but I'm new to all of this too.
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| Posted 10/27/11 9:28 AM |
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Daisy21
My Little Loves
Member since 6/10 1133 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
I have two copies of C and I have been following the same protocol as the above posters.
As a side note, it makes me nervous that the doctors say to take metanx for life because I had been on it since August of 2010 and when I got pregnant and started seeing a peri, he tested my B12 levels. My levels were VERY high. He took me off of the metanx for a month and retested and they were back within normal range. I am back on it now, but I won't be so quick to continue it when I'm not pregnant. I feel like all of these supplements really need to be monitored. It's dangerous to have the levels get so high and I had no idea. I sometimes feel like we are over prescribed meds, but I'm not taking any chances right now.
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| Posted 10/27/11 10:11 AM |
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Leb
LIF Adult
Member since 12/09 4166 total posts
Name:
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by Tylersmom
Posted by Leb
I have a copy of A and C too.
I was told baby aspirin and metnax for life. Also I was told somethign where metnax has "active ingredients", and other vitamins like folgard has "inactive" which doesn't work as well.
I was told lovenox was "too agressive" for me and have been doing intralipids.
SO- is baby aspirin not strong enough for a blood thinner that you and others had to go on intralipids or Lovenox ???
I guess baby aspirin was strong enough for me because he said I didn't need lovenox, and the intralipids weren't for MTHFR, but I believe for NK cells.
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| Posted 10/27/11 12:15 PM |
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Tylersmom
LIF Zygote
Member since 10/11 19 total posts
Name:
Michelle
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Re: Help!! Positive for MTHFR C677t & A1298c and ANA
Posted by FLS2011
Posted by Tylersmom
Posted by FLS2011
Posted by Tylersmom
OK- another question. Lovenox- I noticed a lot you ladies are on it... That is a blood thinner injection, correct? My Dr. prescribed me to take baby aspirin. Do you think i should bring that up with my Dr??? thank you !!!!!
I'm not currently on Lovenox but would be if I got pregnant, along with progesterone. I'm currently on baby aspirin and Folgard (a prescription vitamin that has lots of extra folic acid and helps b/c the MTHFR affects how you process folate). I would definitely bring up any meds that you are on to your Dr.
I'm currently on baby aspirin, Progesterone ,Folgard and prenatals. My Dr. also wants me to go on Clomid (a little hesitant about taking it )
I'll see how this pains out...
I forgot to mention I take a prenatal too. Clomid for clotting issues or something else? I've never heard of it for clotting but I'm new to all of this too.
My Dr. wants me to on Clomid to regulate my cycles (well a better way to ovulate on demand..lol)
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| Posted 10/27/11 10:31 PM |
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