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another estrogen level question! UGH UPDATE!

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smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

another estrogen level question! UGH UPDATE!

Sorry to be a PIA, but i am on day 7 of stimming (have taken 6 injections of Follistim) and my estrogen is 2,112

is that too high? i have another appointment tomorrow morning so they are definitely monitoring me closely, but i think that seems a bit high? i think my ER should be Monday

Thanks!

UPDATE: Ok, so today my Estrogen was 4,100!!!! I am stopping all stims tonight and have another appointment tomorrow. I am hopefully triggering tomorrow, but i am now terrified of OHSS. The nurse keeps telling me i will be fine and to calm down and not get upset and it isn't horrible, but i am petrified now!

Message edited 2/19/2010 7:23:14 PM.

Posted 2/18/10 4:10 PM
 
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Inhidingfornow
LIF Infant

Member since 11/09

240 total posts

Name:

Re: another estrogen level question!

That is high!! at this point E2 levels double each day so if your ER is Monday your E2 levels will be way over 4,000

If estradiol is over 3500 pg/ml, it needs extra attention and estradiol of over 4000 would probably mean cancellation of a cycle.....

What is the size of the follicles?? I am sure they will know more tomorrow and personally I don't think you will make it to Monday for ER....

Message edited 2/18/2010 4:26:31 PM.

Posted 2/18/10 4:25 PM
 

smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

Re: another estrogen level question!

omg i am seriously freaking out!

they dropped my follistim injections from 225 iu to 75 iu and added Menopur for tonight

i go in for another blood work and sono tomorrow so i will make sure they aren't hyperstimming me!

I kinda hope i have my ER before Monday - i am so nervous now.

oh, i dont know the size of the follies - i will def ask tomorrow, but he said they looked good. whatever that means!

thank you for your help!

Message edited 2/18/2010 4:29:30 PM.

Posted 2/18/10 4:28 PM
 

lolipep
My prayers have been answered

Member since 10/08

3642 total posts

Name:
Lori

Re: another estrogen level question!

Please don't worry about it --I am sure your Dr. is monitoring you and will take the necessary steps to help you along and not hyperstimulate.
My estrogen levels were high as well and I had to trigger with lupron instead of HCG shot so that I didn't get OHSS and everything turned out fine

Posted 2/18/10 4:30 PM
 

smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

Re: another estrogen level question!

Posted by lolipep

Please don't worry about it --I am sure your Dr. is monitoring you and will take the necessary steps to help you along and not hyperstimulate.
My estrogen levels were high as well and I had to trigger with lupron instead of HCG shot so that I didn't get OHSS and everything turned out fine



oh thank you!

i feel a little bit better now - i am so just scared something is going to go wrong and ruin this cycle

thank you for your help!

Posted 2/18/10 4:33 PM
 

Inhidingfornow
LIF Infant

Member since 11/09

240 total posts

Name:

Re: another estrogen level question!

Posted by smp123

omg i am seriously freaking out!

they dropped my follistim injections from 225 iu to 75 iu and added Menopur for tonight

i go in for another blood work and sono tomorrow so i will make sure they aren't hyperstimming me!

I kinda hope i have my ER before Monday - i am so nervous now.

oh, i dont know the size of the follies - i will def ask tomorrow, but he said they looked good. whatever that means!

thank you for your help!



Don't freak out!!!

It means you have a lot of activity in there (which is a good thing)!! and I am sure they are monitoring you closely....if the follicle size is right, you will trigger or sometimes they migh "coast" you....adding LH in the Menopur will slow you down a little so they are doing the right thing!


Posted 2/18/10 4:35 PM
 

smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

Re: another estrogen level question!

Posted by Inhidingfornow

Posted by smp123

omg i am seriously freaking out!

they dropped my follistim injections from 225 iu to 75 iu and added Menopur for tonight

i go in for another blood work and sono tomorrow so i will make sure they aren't hyperstimming me!

I kinda hope i have my ER before Monday - i am so nervous now.

oh, i dont know the size of the follies - i will def ask tomorrow, but he said they looked good. whatever that means!

thank you for your help!



Don't freak out!!!

It means you have a lot of activity in there (which is a good thing)!! and I am sure they are monitoring you closely....if the follicle size is right, you will trigger or sometimes they migh "coast" you....adding LH in the Menopur will slow you down a little so they are doing the right thing!





oh really? that's good news too!

thank you so much for your help Chat Icon

i am so new to this, I don't know what's going on half the time!

thank you again for your help!

Posted 2/18/10 4:37 PM
 

Inhidingfornow
LIF Infant

Member since 11/09

240 total posts

Name:

Re: another estrogen level question!

You are welcome!!! Stay calm!!!lol...

This is a great article on E2 levels

As the ovary is stimulated and more follicles are recruited and they get bigger, they produce more estrogen. Hence, the estrogen level increases. The goal is for the estradiol level to be under 4000 so that there is minimal risk of hyperstimulation syndrome, an illness caused by over stimulation of the ovaries. The two risk factors for hyperstimulation syndrome are estradiol over 4000 and 20 or more follicles.

If your level is under 4000, and your lead follicles are at least 18 mms, then you can be triggered with HCG with minimal chances of developing hyperstimulation syndrome. However, if your level is 3800 and your follicles are not yet matured (18mms or more), then there is a high likelihood that your level will go over 4000 before you can be triggered. In this case, doctors will use a "drift" or "coast" to allow the levels to decrease to under 3000 before triggering. Again, this is done to prevent hyperstimulation syndrome. Estradiol levels double every two days (approximately).

If you have to undergo a drift/coast, a procedure whereby the stimulation medications are stopped, and you follow the estradiol levels on a daily basis until the level decreases to where you want them then trigger, some of the follicles will stop growing and the eggs within will begin to deteriorate, but the larger follicles and eggs should be okay.

Another way to decrease the risk of hyperstimulation syndrome, which I recommend, is triggering with Lupron, if you are not on the long protocol using Lupron to suppress the ovaries.

I hope this answers your questions.

Posted 2/18/10 4:40 PM
 

smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

Re: another estrogen level question!

Posted by Inhidingfornow

You are welcome!!! Stay calm!!!lol...

This is a great article on E2 levels

As the ovary is stimulated and more follicles are recruited and they get bigger, they produce more estrogen. Hence, the estrogen level increases. The goal is for the estradiol level to be under 4000 so that there is minimal risk of hyperstimulation syndrome, an illness caused by over stimulation of the ovaries. The two risk factors for hyperstimulation syndrome are estradiol over 4000 and 20 or more follicles.

If your level is under 4000, and your lead follicles are at least 18 mms, then you can be triggered with HCG with minimal chances of developing hyperstimulation syndrome. However, if your level is 3800 and your follicles are not yet matured (18mms or more), then there is a high likelihood that your level will go over 4000 before you can be triggered. In this case, doctors will use a "drift" or "coast" to allow the levels to decrease to under 3000 before triggering. Again, this is done to prevent hyperstimulation syndrome. Estradiol levels double every two days (approximately).

If you have to undergo a drift/coast, a procedure whereby the stimulation medications are stopped, and you follow the estradiol levels on a daily basis until the level decreases to where you want them then trigger, some of the follicles will stop growing and the eggs within will begin to deteriorate, but the larger follicles and eggs should be okay.

Another way to decrease the risk of hyperstimulation syndrome, which I recommend, is triggering with Lupron, if you are not on the long protocol using Lupron to suppress the ovaries.

I hope this answers your questions.



oh wow that's a great article!

thank you!

I am going to ask my doctor 1000 questions tomorrow!

thank you!

Posted 2/18/10 4:42 PM
 

smp123
Praying for the LOs!

Member since 1/09

1630 total posts

Name:

Re: another estrogen level question! UGH UPDATE!

update

Posted 2/19/10 7:23 PM
 
 

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